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Department of Bioorganic Chemistry

Stereoviews showing the conformation at the self-cleavage sites of the lariat tetramer 14, hexamer 18 (A- and B-form), and heptamer 19 (G3 and C6 / U7) from snapshots at 226 ps. All water molecules, sodium ions, and hydrogen atoms have been omitted for clarity. The O3'-PO2-O5' fragments are shown as ball and stick models while the remainder is shown as wireframe. Structures of the lariat hexamer and lariat heptamer are taken from Rousse, B. et al., Tetrahedron,50, 1777-1810 (1994).

Panel (A): Tetramer 14 (P of G3 = -12°, e = 168°, z = 33°, a = -137°, b = -169°, g = 51° and P of C6 = 18°). Panel (B): Hexamer A-form (P of G3 = 44°, e = -158°, z = -58°, a = -80°, b = 171°, g = 68° and P of C6 = 53°). Panel (C): Hexamer B-form (P of G3 = 177°, e = -151°, z = 78°, a = 85°, b = 178°, g = 67° and P of C6 = 37°). Panel (D): Heptamer (P of G3 = 123°, e = -96°, z = 146°, a = 64°, b = -176°, g = 54° and P of U7 = 150°).


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