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Department of Bioorganic Chemistry

Research at the Department of Bioorganic Chemistry

Summary of the current research activities (Research Projects)  :

The current research activities at the Department are conducted in the following frontiers:

Goals
  • The synthetic activities (Research Projects) are expected to lead us to the development of new chemicals and reagents as potential gene-directed pharmaceuticals and diagnostics for the down-regulation of gene expression.
  • Elucidation of Bioorganic Mechanisms using synthetic physical and structural (NMR) chemistry to model transition state or the intermediate of biochemical reactions, such as splicing, RNA catalysis, and DNA/RNA-ligand  interactions.
  • The structural studies encompassing both high-field NMR and computational chemistry (Research Projects) are being used to shed light on the general principles of stereoelectronic make-up, electrostatics, hydrogen-bonding, hydration and hydrophobic interactions of nucleosides, nucleotides and oligonucleotides and their complexes. 
  • On the other hand, the kinetic analysis of important chemical reactions such as RNase H promoted cleavage of the hybrid duplex of the antisense oligo and the target RNA sheds light on the energetics of the intermediates and their transition states to better understand the design principles of the enzyme substrates.
  • Thus a dynamic and  iterative  interplay of  Synthetic Chemistry, Enzymolgy of Nucleic Acid-Protein Complexes and Structuralstudies using NMR and Computation is being found useful for the design and synthesis of improved nucleic acid based therapeutics or inhibitors, as well as to further our understanding of how the structure and dynamics of nucleic acids and its complexes with various ligands dictate their unique biological function. 
  • We expect this Bioorganic Approach will enhance our understanding at the Chemistry-Biology interface.

Are you interested in participating in our research?

We welcome new scientific collaborators both for doctoral and postdoctoral studies. For some hints for new recruits for doctoral studies, see "How to become a Ph.D student".
Contact Prof. Jyoti Chattopadhyaya by e-mail, phone or mail for more details. 


Bioorg. Chem. | Last mod.: Sept. 7, 2012 | URL http://www.boc.uu.se/ | WebMaster | WWW Editor