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'Synthesis of Nucleic Acids' reseach at the Department
of Bioorganic Chemistry
The Dep't of Bioorganic Chemistry has for many years worked on the development
of new protecting groups and phosphorilation techniques as well as sugar
chemistry for the chemical synthesis of native and modified DNA and RNA
fragments. Much work has also been done for strategies for RNA and DNA
synthesis. Highlights of these activities can be summurized through the
branch and lariate RNA synthesis [201,195,193,185,183,190].
Synthetic lariate RNAs showed site-specific self-clevage reactions (see,
for example, Refs. 217,224,240).
The development of the synthesis of isotope
labelled nucleic acids which are to be used in conformational studies
using NMR spectroscopy is one of the major areas of research at the department
Dep't of Bioorg. Chem. | Last mod.: Feb 14, 2002
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